Pathway report - 370727
Source/TargetNodesConfidenceGO AnnotationKEGG AnnotationMSigDB Annotation
PIK3C3 --> CASP3 PIK3C3 -> YWHAG -> KIF23 -> BIRC6 -> CASP3 0.27624043690535enzyme inhibitor activity(0.001338)NE(1)REGULATION_OF_DEVELOPMENTAL_PROCESS(1.427e-05)
MTOR --> CASP3 MTOR -> ULK1 -> RB1CC1 -> TRAF2 -> BIRC3 -> CASP3 0.587396713382regulation of T cell activation(0.0001291)Apoptosis(6.219e-05)ST_TUMOR_NECROSIS_FACTOR_PATHWAY(7.407e-09)
MTOR --> CASP3 MTOR -> ULK1 -> RB1CC1 -> TRAF2 -> RIPK1 -> UBC -> BIRC2 -> CASP3 0.586914461161979biopolymer catabolic process(5.972e-05)Apoptosis(3.098e-06)ST_TUMOR_NECROSIS_FACTOR_PATHWAY(1.729e-11)
MTOR --> CASP3 MTOR -> ULK1 -> RB1CC1 -> TRAF2 -> RIPK1 -> TNFRSF1A -> CASP10 -> CASP3 0.58615143234963caspase activity(1.887e-05)Apoptosis(3.569e-08)APOPTOSIS_KEGG(1.583e-13)
MTOR --> CASP3 MTOR -> ULK1 -> RB1CC1 -> TRAF2 -> RIPK1 -> UBC -> TRAF6 -> MAP3K7IP1 -> XIAP -> CASP3 0.585581579752976positive regulation of multicellular organismal process(6.384e-07)Apoptosis(9.082e-06)DEATHPATHWAY(8.925e-11)
MTOR --> CASP3 MTOR -> ULK1 -> RB1CC1 -> TRAF2 -> RIPK1 -> SQSTM1 -> TRAF6 -> UBC -> BIRC2 -> CASP3 0.585189952938262positive regulation of multicellular organismal process(6.384e-07)Apoptosis(9.082e-06)I_KAPPAB_KINASE_NF_KAPPAB_CASCADE(4.893e-11)
MTOR --> CASP3 MTOR -> ULK1 -> RB1CC1 -> TRAF2 -> CASP8 -> CASP3 0.58418891106caspase activity(1.012e-05)Apoptosis(6.219e-05)TNFR1PATHWAY(7.407e-09)
MTOR --> CASP3 MTOR -> ULK1 -> RB1CC1 -> TRAF2 -> RIPK1 -> SQSTM1 -> TRAF6 -> MAP3K7IP1 -> XIAP -> CASP3 0.583862155607248positive regulation of T cell mediated immunity(7.602e-07)Apoptosis(9.082e-06)DEATHPATHWAY(8.925e-11)
MTOR --> CASP3 MTOR -> ULK1 -> RB1CC1 -> TRAF2 -> RIPK1 -> CFLAR -> CASP8 -> CASP3 0.573626959626899caspase activity(2.805e-08)Apoptosis(3.569e-08)ST_TUMOR_NECROSIS_FACTOR_PATHWAY(8.885e-15)
MTOR --> CASP3 MTOR -> ULK1 -> RB1CC1 -> TRAF2 -> RIPK1 -> CRADD -> CASP2 -> CASP3 0.573626959626899caspase activity(2.805e-08)Apoptosis(0.0001704)TNFR1PATHWAY(8.885e-15)
MTOR --> CASP3 MTOR -> ULK1 -> RB1CC1 -> TRAF2 -> RIPK1 -> CFLAR -> CASP10 -> CASP3 0.573626959626899caspase activity(2.805e-08)Apoptosis(3.569e-08)DEATHPATHWAY(1.775e-14)
RB1CC1 --> CASP3 RB1CC1 -> TRAF2 -> BIRC3 -> CASP3 0.587396713382regulation of apoptosis(3.308e-05)Apoptosis(1.271e-05)ST_TUMOR_NECROSIS_FACTOR_PATHWAY(1.483e-09)
RB1CC1 --> CASP3 RB1CC1 -> TRAF2 -> RIPK1 -> UBC -> BIRC2 -> CASP3 0.586914461161979positive regulation of multicellular organismal process(4.718e-05)Apoptosis(6.792e-07)ST_TUMOR_NECROSIS_FACTOR_PATHWAY(3.71e-12)
RB1CC1 --> CASP3 RB1CC1 -> TRAF2 -> RIPK1 -> TNFRSF1A -> CASP10 -> CASP3 0.58615143234963caspase activity(1.012e-05)Apoptosis(3.916e-09)APOPTOSIS_KEGG(1.699e-14)
RB1CC1 --> CASP3 RB1CC1 -> TRAF2 -> RIPK1 -> UBC -> TRAF6 -> MAP3K7IP1 -> XIAP -> CASP3 0.585581579752976positive regulation of multicellular organismal process(2.987e-07)Apoptosis(3.098e-06)DEATHPATHWAY(2.979e-11)
RB1CC1 --> CASP3 RB1CC1 -> TRAF2 -> RIPK1 -> SQSTM1 -> TRAF6 -> UBC -> BIRC2 -> CASP3 0.585189952938262positive regulation of multicellular organismal process(2.987e-07)Apoptosis(3.098e-06)I_KAPPAB_KINASE_NF_KAPPAB_CASCADE(1.092e-11)
RB1CC1 --> CASP3 RB1CC1 -> TRAF2 -> CASP8 -> CASP3 0.58418891106caspase activity(4.051e-06)Apoptosis(1.271e-05)TNFR1PATHWAY(1.483e-09)
RB1CC1 --> CASP3 RB1CC1 -> TRAF2 -> RIPK1 -> SQSTM1 -> TRAF6 -> MAP3K7IP1 -> XIAP -> CASP3 0.583862155607248regulation of protein kinase activity(3.083e-07)Apoptosis(3.098e-06)DEATHPATHWAY(2.979e-11)
RB1CC1 --> CASP3 RB1CC1 -> TRAF2 -> RIPK1 -> CFLAR -> CASP10 -> CASP3 0.573626959626899caspase activity(1.003e-08)Apoptosis(3.916e-09)DEATHPATHWAY(1.904e-15)
RB1CC1 --> CASP3 RB1CC1 -> TRAF2 -> RIPK1 -> CRADD -> CASP2 -> CASP3 0.573626959626899caspase activity(1.003e-08)Apoptosis(6.219e-05)TNFR1PATHWAY(9.529e-16)
RB1CC1 --> CASP3 RB1CC1 -> TRAF2 -> RIPK1 -> CFLAR -> CASP8 -> CASP3 0.573626959626899caspase activity(1.003e-08)Apoptosis(3.916e-09)ST_TUMOR_NECROSIS_FACTOR_PATHWAY(9.529e-16)
ATG16L1 --> CASP3 ATG16L1 -> ATG5 -> DEDD -> CASP8 -> CASP3 0.999972autophagic vacuole(5.631e-07)NE(1)ST_FAS_SIGNALING_PATHWAY(4.634e-08)
PIK3R4 --> CASP3 PIK3R4 -> PIK3C3 -> YWHAG -> KIF23 -> BIRC6 -> CASP3 0.27624043690535receptor signaling complex scaffold activity(0.0008176)Regulation of autophagy(0.0009139)UVB_NHEK1_DN(6.485e-06)
AMBRA-1 --> CASP3 AMBRA-1 -> BECN1 -> PIK3C3 -> YWHAG -> KIF23 -> BIRC6 -> CASP3 0.27624043690535NE(1)Regulation of autophagy(0.001273)REGULATION_OF_DEVELOPMENTAL_PROCESS(5.57e-07)
ATG12 --> CASP3 ATG12 -> ATG5 -> DEDD -> CASP8 -> CASP3 0.999972autophagic vacuole formation(3.379e-07)Regulation of autophagy(0.0006124)ST_FAS_SIGNALING_PATHWAY(4.634e-08)
ULK1 --> CASP3 ULK1 -> RB1CC1 -> TRAF2 -> BIRC3 -> CASP3 0.587396713382regulation of apoptosis(8.145e-05)Apoptosis(3.143e-05)ST_TUMOR_NECROSIS_FACTOR_PATHWAY(3.705e-09)
ULK1 --> CASP3 ULK1 -> RB1CC1 -> TRAF2 -> RIPK1 -> UBC -> BIRC2 -> CASP3 0.586914461161979positive regulation of multicellular organismal process(6.598e-05)Apoptosis(1.567e-06)ST_TUMOR_NECROSIS_FACTOR_PATHWAY(8.652e-12)
ULK1 --> CASP3 ULK1 -> RB1CC1 -> TRAF2 -> RIPK1 -> TNFRSF1A -> CASP10 -> CASP3 0.58615143234963caspase activity(1.416e-05)Apoptosis(1.354e-08)APOPTOSIS_KEGG(5.942e-14)
ULK1 --> CASP3 ULK1 -> RB1CC1 -> TRAF2 -> RIPK1 -> UBC -> TRAF6 -> MAP3K7IP1 -> XIAP -> CASP3 0.585581579752976positive regulation of multicellular organismal process(4.475e-07)Apoptosis(5.512e-06)DEATHPATHWAY(5.358e-11)
ULK1 --> CASP3 ULK1 -> RB1CC1 -> TRAF2 -> RIPK1 -> SQSTM1 -> TRAF6 -> UBC -> BIRC2 -> CASP3 0.585189952938262positive regulation of multicellular organismal process(4.475e-07)Apoptosis(5.512e-06)I_KAPPAB_KINASE_NF_KAPPAB_CASCADE(2.452e-11)
ULK1 --> CASP3 ULK1 -> RB1CC1 -> TRAF2 -> CASP8 -> CASP3 0.58418891106caspase activity(6.749e-06)Apoptosis(3.143e-05)TNFR1PATHWAY(3.705e-09)
ULK1 --> CASP3 ULK1 -> RB1CC1 -> TRAF2 -> RIPK1 -> SQSTM1 -> TRAF6 -> MAP3K7IP1 -> XIAP -> CASP3 0.583862155607248regulation of protein kinase activity(5.514e-07)Apoptosis(5.512e-06)DEATHPATHWAY(5.358e-11)
ULK1 --> CASP3 ULK1 -> RB1CC1 -> TRAF2 -> RIPK1 -> CFLAR -> CASP10 -> CASP3 0.573626959626899caspase activity(1.754e-08)Apoptosis(1.354e-08)DEATHPATHWAY(6.661e-15)
ULK1 --> CASP3 ULK1 -> RB1CC1 -> TRAF2 -> RIPK1 -> CFLAR -> CASP8 -> CASP3 0.573626959626899caspase activity(1.754e-08)Apoptosis(1.354e-08)ST_TUMOR_NECROSIS_FACTOR_PATHWAY(3.334e-15)
ULK1 --> CASP3 ULK1 -> RB1CC1 -> TRAF2 -> RIPK1 -> CRADD -> CASP2 -> CASP3 0.573626959626899caspase activity(1.754e-08)Apoptosis(0.0001077)TNFR1PATHWAY(3.334e-15)
MAP1LC3B --> CASP3 MAP1LC3B -> SQSTM1 -> RIPK1 -> TRAF2 -> BIRC3 -> CASP3 0.338891775545688regulation of T cell activation(0.0001291)Apoptosis(6.792e-07)ST_TUMOR_NECROSIS_FACTOR_PATHWAY(3.71e-12)
MAP1LC3B --> CASP3 MAP1LC3B -> SQSTM1 -> RIPK1 -> UBC -> BIRC2 -> CASP3 0.338619640801963NE(1)Apoptosis(6.219e-05)ST_TUMOR_NECROSIS_FACTOR_PATHWAY(7.407e-09)
MAP1LC3B --> CASP3 MAP1LC3B -> SQSTM1 -> TRAF6 -> UBC -> RIPK1 -> TRAF2 -> BIRC3 -> CASP3 0.338450177781positive regulation of multicellular organismal process(2.987e-07)Apoptosis(3.098e-06)ST_TUMOR_NECROSIS_FACTOR_PATHWAY(1.729e-11)
MAP1LC3B --> CASP3 MAP1LC3B -> SQSTM1 -> RIPK1 -> TNFRSF1A -> CASP10 -> CASP3 0.338179412183558caspase activity(1.012e-05)Apoptosis(6.792e-07)APOPTOSIS_KEGG(3.594e-11)
MAP1LC3B --> CASP3 MAP1LC3B -> SQSTM1 -> RIPK1 -> UBC -> TRAF6 -> MAP3K7IP1 -> XIAP -> CASP3 0.337850636366368regulation of protein kinase activity(3.023e-05)Apoptosis(0.0001704)NFKBPATHWAY(1.005e-08)
MAP1LC3B --> CASP3 MAP1LC3B -> SQSTM1 -> TRAF6 -> UBC -> RIPK1 -> TNFRSF1A -> CASP10 -> CASP3 0.337738742674116positive regulation of cellular process(3.315e-06)Apoptosis(3.098e-06)APOPTOSIS_KEGG(1.583e-13)
MAP1LC3B --> CASP3 MAP1LC3B -> SQSTM1 -> RIPK1 -> TRAF2 -> CASP8 -> CASP3 0.337041070903092caspase activity(1.012e-05)Apoptosis(6.792e-07)TNFR1PATHWAY(3.71e-12)
MAP1LC3B --> CASP3 MAP1LC3B -> SQSTM1 -> TRAF6 -> UBC -> RIPK1 -> TRAF2 -> CASP8 -> CASP3 0.336601884725501positive regulation of multicellular organismal process(2.987e-07)Apoptosis(3.098e-06)APOPTOSIS_KEGG(1.583e-13)
MAP1LC3B --> CASP3 MAP1LC3B -> SQSTM1 -> RIPK1 -> CFLAR -> CASP8 -> CASP3 0.330953431678309caspase activity(1.003e-08)Apoptosis(6.792e-07)ST_TUMOR_NECROSIS_FACTOR_PATHWAY(3.71e-12)
MAP1LC3B --> CASP3 MAP1LC3B -> SQSTM1 -> RIPK1 -> CRADD -> CASP2 -> CASP3 0.330953431678309caspase activity(1.003e-08)NA(1)TNFR1PATHWAY(3.71e-12)
MAP1LC3B --> CASP3 MAP1LC3B -> SQSTM1 -> RIPK1 -> CFLAR -> CASP10 -> CASP3 0.330953431678309caspase activity(1.003e-08)Apoptosis(6.792e-07)DEATHPATHWAY(6.39e-12)
MAP1LC3B --> CASP3 MAP1LC3B -> SQSTM1 -> TRAF6 -> UBC -> RIPK1 -> CFLAR -> CASP8 -> CASP3 0.330522178085891caspase activity(2.805e-08)Apoptosis(3.098e-06)REGULATION_OF_I_KAPPAB_KINASE_NF_KAPPAB_CASCADE(3.872e-12)
MAP1LC3B --> CASP3 MAP1LC3B -> SQSTM1 -> TRAF6 -> UBC -> RIPK1 -> CFLAR -> CASP10 -> CASP3 0.330522178085891caspase activity(2.805e-08)Apoptosis(3.098e-06)DEATHPATHWAY(2.979e-11)
MAP1LC3B --> CASP3 MAP1LC3B -> SQSTM1 -> TRAF6 -> UBC -> RIPK1 -> CRADD -> CASP2 -> CASP3 0.330522178085891caspase activity(2.805e-08)NE(1)APOPTOSIS_KEGG(1.583e-13)
MAP1LC3B --> CASP3 MAP1LC3B -> SQSTM1 -> RIPK1 -> CFLAR -> CASP8 -> TRAF2 -> BIRC3 -> CASP3 0.329140154118981caspase activity(2.805e-08)Apoptosis(2.543e-10)ST_TUMOR_NECROSIS_FACTOR_PATHWAY(2.739e-18)
MAP1LC3B --> CASP3 MAP1LC3B -> SQSTM1 -> TRAF6 -> UBC -> RIPK1 -> CFLAR -> CASP8 -> TRAF2 -> BIRC3 -> CASP3 0.328711263343766positive regulation of cellular process(9.336e-09)Apoptosis(1.862e-09)ST_TUMOR_NECROSIS_FACTOR_PATHWAY(2.052e-17)
BECN1 --> CASP3 BECN1 -> PIK3C3 -> YWHAG -> KIF23 -> BIRC6 -> CASP3 0.27624043690535regulation of apoptosis(0.0001604)Regulation of autophagy(0.0009139)REGULATION_OF_DEVELOPMENTAL_PROCESS(2.409e-07)
ATG3 --> CASP3 ATG3 -> MAP1LC3B -> SQSTM1 -> RIPK1 -> TRAF2 -> BIRC3 -> CASP3 0.338891775545688NE(1)Apoptosis(1.567e-06)ST_TUMOR_NECROSIS_FACTOR_PATHWAY(8.652e-12)
ATG3 --> CASP3 ATG3 -> MAP1LC3B -> SQSTM1 -> RIPK1 -> UBC -> BIRC2 -> CASP3 0.338619640801963NE(1)Apoptosis(0.0001077)ST_TUMOR_NECROSIS_FACTOR_PATHWAY(1.296e-08)
ATG3 --> CASP3 ATG3 -> MAP1LC3B -> SQSTM1 -> TRAF6 -> UBC -> RIPK1 -> TRAF2 -> BIRC3 -> CASP3 0.338450177781positive regulation of multicellular organismal process(4.475e-07)Apoptosis(5.512e-06)ST_TUMOR_NECROSIS_FACTOR_PATHWAY(3.111e-11)
ATG3 --> CASP3 ATG3 -> MAP1LC3B -> SQSTM1 -> RIPK1 -> TNFRSF1A -> CASP10 -> CASP3 0.338179412183558caspase activity(1.416e-05)Apoptosis(1.567e-06)APOPTOSIS_KEGG(8.378e-11)
ATG3 --> CASP3 ATG3 -> MAP1LC3B -> SQSTM1 -> RIPK1 -> UBC -> TRAF6 -> MAP3K7IP1 -> XIAP -> CASP3 0.337850636366368regulation of protein kinase activity(4.507e-05)Apoptosis(0.0002528)NFKBPATHWAY(1.507e-08)
ATG3 --> CASP3 ATG3 -> MAP1LC3B -> SQSTM1 -> TRAF6 -> UBC -> RIPK1 -> TNFRSF1A -> CASP10 -> CASP3 0.337738742674116positive regulation of cellular process(7.233e-06)Apoptosis(5.512e-06)APOPTOSIS_KEGG(3.558e-13)
ATG3 --> CASP3 ATG3 -> MAP1LC3B -> SQSTM1 -> RIPK1 -> TRAF2 -> CASP8 -> CASP3 0.337041070903092caspase activity(1.416e-05)Apoptosis(1.567e-06)TNFR1PATHWAY(8.652e-12)
ATG3 --> CASP3 ATG3 -> MAP1LC3B -> SQSTM1 -> TRAF6 -> UBC -> RIPK1 -> TRAF2 -> CASP8 -> CASP3 0.336601884725501positive regulation of multicellular organismal process(4.475e-07)Apoptosis(5.512e-06)APOPTOSIS_KEGG(3.558e-13)
ATG3 --> CASP3 ATG3 -> MAP1LC3B -> SQSTM1 -> RIPK1 -> CRADD -> CASP2 -> CASP3 0.330953431678309caspase activity(1.754e-08)Apoptosis(0.004404)TNFR1PATHWAY(8.652e-12)
ATG3 --> CASP3 ATG3 -> MAP1LC3B -> SQSTM1 -> RIPK1 -> CFLAR -> CASP8 -> CASP3 0.330953431678309caspase activity(1.754e-08)Apoptosis(1.567e-06)ST_TUMOR_NECROSIS_FACTOR_PATHWAY(8.652e-12)
ATG3 --> CASP3 ATG3 -> MAP1LC3B -> SQSTM1 -> RIPK1 -> CFLAR -> CASP10 -> CASP3 0.330953431678309caspase activity(1.754e-08)Apoptosis(1.567e-06)DEATHPATHWAY(1.49e-11)
ATG3 --> CASP3 ATG3 -> MAP1LC3B -> SQSTM1 -> TRAF6 -> UBC -> RIPK1 -> CFLAR -> CASP8 -> CASP3 0.330522178085891caspase activity(4.206e-08)Apoptosis(5.512e-06)REGULATION_OF_I_KAPPAB_KINASE_NF_KAPPAB_CASCADE(8.696e-12)
ATG3 --> CASP3 ATG3 -> MAP1LC3B -> SQSTM1 -> TRAF6 -> UBC -> RIPK1 -> CRADD -> CASP2 -> CASP3 0.330522178085891caspase activity(4.206e-08)NE(1)APOPTOSIS_KEGG(3.558e-13)
ATG3 --> CASP3 ATG3 -> MAP1LC3B -> SQSTM1 -> TRAF6 -> UBC -> RIPK1 -> CFLAR -> CASP10 -> CASP3 0.330522178085891caspase activity(4.206e-08)Apoptosis(5.512e-06)DEATHPATHWAY(5.358e-11)
ATG3 --> CASP3 ATG3 -> MAP1LC3B -> SQSTM1 -> RIPK1 -> CFLAR -> CASP8 -> TRAF2 -> BIRC3 -> CASP3 0.329140154118981caspase activity(4.206e-08)Apoptosis(7.538e-10)ST_TUMOR_NECROSIS_FACTOR_PATHWAY(8.212e-18)
ATG3 --> CASP3 ATG3 -> MAP1LC3B -> SQSTM1 -> TRAF6 -> UBC -> RIPK1 -> CFLAR -> CASP8 -> TRAF2 -> BIRC3 -> CASP3 0.328711263343766positive regulation of cellular process(2.486e-08)Apoptosis(4.047e-09)ST_TUMOR_NECROSIS_FACTOR_PATHWAY(4.512e-17)
ATG10 --> CASP3 ATG10 -> ATG5 -> DEDD -> CASP8 -> CASP3 0.999972autophagy(2.533e-06)NE(1)ST_FAS_SIGNALING_PATHWAY(4.634e-08)
DAPK1 --> CASP3 DAPK1 -> BECN1 -> PIK3C3 -> YWHAG -> KIF23 -> BIRC6 -> CASP3 0.27624043690535regulation of apoptosis(5.66e-06)Regulation of autophagy(0.001273)REGULATION_OF_DEVELOPMENTAL_PROCESS(3.79e-09)
ATG7 --> CASP3 ATG7 -> MAP1LC3B -> SQSTM1 -> RIPK1 -> TRAF2 -> BIRC3 -> CASP3 0.338891775545688NE(1)Apoptosis(1.567e-06)ST_TUMOR_NECROSIS_FACTOR_PATHWAY(8.652e-12)
ATG7 --> CASP3 ATG7 -> MAP1LC3B -> SQSTM1 -> RIPK1 -> UBC -> BIRC2 -> CASP3 0.338619640801963NE(1)Apoptosis(0.0001077)ST_TUMOR_NECROSIS_FACTOR_PATHWAY(1.296e-08)
ATG7 --> CASP3 ATG7 -> MAP1LC3B -> SQSTM1 -> TRAF6 -> UBC -> RIPK1 -> TRAF2 -> BIRC3 -> CASP3 0.338450177781positive regulation of multicellular organismal process(4.475e-07)Apoptosis(5.512e-06)ST_TUMOR_NECROSIS_FACTOR_PATHWAY(3.111e-11)
ATG7 --> CASP3 ATG7 -> MAP1LC3B -> SQSTM1 -> RIPK1 -> TNFRSF1A -> CASP10 -> CASP3 0.338179412183558caspase activity(1.416e-05)Apoptosis(1.567e-06)APOPTOSIS_KEGG(8.378e-11)
ATG7 --> CASP3 ATG7 -> MAP1LC3B -> SQSTM1 -> RIPK1 -> UBC -> TRAF6 -> MAP3K7IP1 -> XIAP -> CASP3 0.337850636366368regulation of protein kinase activity(4.507e-05)Apoptosis(0.0002528)NFKBPATHWAY(1.507e-08)
ATG7 --> CASP3 ATG7 -> MAP1LC3B -> SQSTM1 -> TRAF6 -> UBC -> RIPK1 -> TNFRSF1A -> CASP10 -> CASP3 0.337738742674116positive regulation of cellular process(7.233e-06)Apoptosis(5.512e-06)APOPTOSIS_KEGG(3.558e-13)
ATG7 --> CASP3 ATG7 -> MAP1LC3B -> SQSTM1 -> RIPK1 -> TRAF2 -> CASP8 -> CASP3 0.337041070903092caspase activity(1.416e-05)Apoptosis(1.567e-06)TNFR1PATHWAY(8.652e-12)
ATG7 --> CASP3 ATG7 -> MAP1LC3B -> SQSTM1 -> TRAF6 -> UBC -> RIPK1 -> TRAF2 -> CASP8 -> CASP3 0.336601884725501positive regulation of multicellular organismal process(4.475e-07)Apoptosis(5.512e-06)APOPTOSIS_KEGG(3.558e-13)
ATG7 --> CASP3 ATG7 -> MAP1LC3B -> SQSTM1 -> RIPK1 -> CFLAR -> CASP10 -> CASP3 0.330953431678309caspase activity(1.754e-08)Apoptosis(1.567e-06)DEATHPATHWAY(1.49e-11)
ATG7 --> CASP3 ATG7 -> MAP1LC3B -> SQSTM1 -> RIPK1 -> CFLAR -> CASP8 -> CASP3 0.330953431678309caspase activity(1.754e-08)Apoptosis(1.567e-06)ST_TUMOR_NECROSIS_FACTOR_PATHWAY(8.652e-12)
ATG7 --> CASP3 ATG7 -> MAP1LC3B -> SQSTM1 -> RIPK1 -> CRADD -> CASP2 -> CASP3 0.330953431678309caspase activity(1.754e-08)Apoptosis(0.004404)TNFR1PATHWAY(8.652e-12)
ATG7 --> CASP3 ATG7 -> MAP1LC3B -> SQSTM1 -> TRAF6 -> UBC -> RIPK1 -> CRADD -> CASP2 -> CASP3 0.330522178085891caspase activity(4.206e-08)NE(1)APOPTOSIS_KEGG(3.558e-13)
ATG7 --> CASP3 ATG7 -> MAP1LC3B -> SQSTM1 -> TRAF6 -> UBC -> RIPK1 -> CFLAR -> CASP8 -> CASP3 0.330522178085891caspase activity(4.206e-08)Apoptosis(5.512e-06)REGULATION_OF_I_KAPPAB_KINASE_NF_KAPPAB_CASCADE(8.696e-12)
ATG7 --> CASP3 ATG7 -> MAP1LC3B -> SQSTM1 -> TRAF6 -> UBC -> RIPK1 -> CFLAR -> CASP10 -> CASP3 0.330522178085891caspase activity(4.206e-08)Apoptosis(5.512e-06)POSITIVE_REGULATION_OF_CELLULAR_PROCESS(1.492e-11)
ATG7 --> CASP3 ATG7 -> MAP1LC3B -> SQSTM1 -> RIPK1 -> CFLAR -> CASP8 -> TRAF2 -> BIRC3 -> CASP3 0.329140154118981caspase activity(4.206e-08)Apoptosis(7.538e-10)ST_TUMOR_NECROSIS_FACTOR_PATHWAY(8.212e-18)
ATG7 --> CASP3 ATG7 -> MAP1LC3B -> SQSTM1 -> TRAF6 -> UBC -> RIPK1 -> CFLAR -> CASP8 -> TRAF2 -> BIRC3 -> CASP3 0.328711263343766positive regulation of cellular process(2.486e-08)Apoptosis(4.047e-09)ST_TUMOR_NECROSIS_FACTOR_PATHWAY(4.512e-17)
ATG13 --> CASP3 ATG13 -> ULK1 -> RB1CC1 -> TRAF2 -> BIRC3 -> CASP3 0.587396713382regulation of T cell activation(0.0001291)Apoptosis(6.219e-05)ST_TUMOR_NECROSIS_FACTOR_PATHWAY(7.407e-09)
ATG13 --> CASP3 ATG13 -> ULK1 -> RB1CC1 -> TRAF2 -> RIPK1 -> UBC -> BIRC2 -> CASP3 0.586914461161979positive regulation of multicellular organismal process(8.788e-05)Apoptosis(3.098e-06)ST_TUMOR_NECROSIS_FACTOR_PATHWAY(1.729e-11)
ATG13 --> CASP3 ATG13 -> ULK1 -> RB1CC1 -> TRAF2 -> RIPK1 -> TNFRSF1A -> CASP10 -> CASP3 0.58615143234963caspase activity(1.887e-05)Apoptosis(3.569e-08)APOPTOSIS_KEGG(1.583e-13)
ATG13 --> CASP3 ATG13 -> ULK1 -> RB1CC1 -> TRAF2 -> RIPK1 -> UBC -> TRAF6 -> MAP3K7IP1 -> XIAP -> CASP3 0.585581579752976positive regulation of multicellular organismal process(6.384e-07)Apoptosis(9.082e-06)DEATHPATHWAY(8.925e-11)
ATG13 --> CASP3 ATG13 -> ULK1 -> RB1CC1 -> TRAF2 -> RIPK1 -> SQSTM1 -> TRAF6 -> UBC -> BIRC2 -> CASP3 0.585189952938262positive regulation of multicellular organismal process(6.384e-07)Apoptosis(9.082e-06)I_KAPPAB_KINASE_NF_KAPPAB_CASCADE(4.893e-11)
ATG13 --> CASP3 ATG13 -> ULK1 -> RB1CC1 -> TRAF2 -> CASP8 -> CASP3 0.58418891106caspase activity(1.012e-05)Apoptosis(6.219e-05)TNFR1PATHWAY(7.407e-09)
ATG13 --> CASP3 ATG13 -> ULK1 -> RB1CC1 -> TRAF2 -> RIPK1 -> SQSTM1 -> TRAF6 -> MAP3K7IP1 -> XIAP -> CASP3 0.583862155607248positive regulation of T cell mediated immunity(7.602e-07)Apoptosis(9.082e-06)DEATHPATHWAY(8.925e-11)
ATG13 --> CASP3 ATG13 -> ULK1 -> RB1CC1 -> TRAF2 -> RIPK1 -> CFLAR -> CASP8 -> CASP3 0.573626959626899caspase activity(2.805e-08)Apoptosis(3.569e-08)ST_TUMOR_NECROSIS_FACTOR_PATHWAY(8.885e-15)
ATG13 --> CASP3 ATG13 -> ULK1 -> RB1CC1 -> TRAF2 -> RIPK1 -> CRADD -> CASP2 -> CASP3 0.573626959626899caspase activity(2.805e-08)Apoptosis(0.0001704)TNFR1PATHWAY(8.885e-15)
ATG13 --> CASP3 ATG13 -> ULK1 -> RB1CC1 -> TRAF2 -> RIPK1 -> CFLAR -> CASP10 -> CASP3 0.573626959626899caspase activity(2.805e-08)Apoptosis(3.569e-08)DEATHPATHWAY(1.775e-14)
ATG5 --> CASP3 ATG5 -> DEDD -> CASP8 -> CASP3 0.999972induction of apoptosis via death domain receptors(2.229e-06)Apoptosis(0.001296)ST_FAS_SIGNALING_PATHWAY(1.856e-08)
ATG4B --> CASP3 ATG4B -> MAP1LC3B -> SQSTM1 -> RIPK1 -> TRAF2 -> BIRC3 -> CASP3 0.338891775545688autophagy(5.315e-06)Apoptosis(1.567e-06)ST_TUMOR_NECROSIS_FACTOR_PATHWAY(8.652e-12)
ATG4B --> CASP3 ATG4B -> MAP1LC3B -> SQSTM1 -> RIPK1 -> UBC -> BIRC2 -> CASP3 0.338619640801963autophagy(5.315e-06)Apoptosis(0.0001077)ST_TUMOR_NECROSIS_FACTOR_PATHWAY(1.296e-08)
ATG4B --> CASP3 ATG4B -> MAP1LC3B -> SQSTM1 -> TRAF6 -> UBC -> RIPK1 -> TRAF2 -> BIRC3 -> CASP3 0.338450177781positive regulation of multicellular organismal process(4.475e-07)Apoptosis(5.512e-06)ST_TUMOR_NECROSIS_FACTOR_PATHWAY(3.111e-11)
ATG4B --> CASP3 ATG4B -> MAP1LC3B -> SQSTM1 -> RIPK1 -> TNFRSF1A -> CASP10 -> CASP3 0.338179412183558cysteine-type peptidase activity(1.275e-06)Apoptosis(1.567e-06)APOPTOSIS_KEGG(8.378e-11)
ATG4B --> CASP3 ATG4B -> MAP1LC3B -> SQSTM1 -> RIPK1 -> UBC -> TRAF6 -> MAP3K7IP1 -> XIAP -> CASP3 0.337850636366368ubiquitin cycle(3.025e-06)Apoptosis(0.0002528)NFKBPATHWAY(1.507e-08)
ATG4B --> CASP3 ATG4B -> MAP1LC3B -> SQSTM1 -> TRAF6 -> UBC -> RIPK1 -> TNFRSF1A -> CASP10 -> CASP3 0.337738742674116ubiquitin cycle(3.025e-06)Apoptosis(5.512e-06)APOPTOSIS_KEGG(3.558e-13)
ATG4B --> CASP3 ATG4B -> MAP1LC3B -> SQSTM1 -> RIPK1 -> TRAF2 -> CASP8 -> CASP3 0.337041070903092cysteine-type peptidase activity(1.275e-06)Apoptosis(1.567e-06)TNFR1PATHWAY(8.652e-12)
ATG4B --> CASP3 ATG4B -> MAP1LC3B -> SQSTM1 -> TRAF6 -> UBC -> RIPK1 -> TRAF2 -> CASP8 -> CASP3 0.336601884725501positive regulation of multicellular organismal process(4.475e-07)Apoptosis(5.512e-06)APOPTOSIS_KEGG(3.558e-13)
ATG4B --> CASP3 ATG4B -> MAP1LC3B -> SQSTM1 -> RIPK1 -> CRADD -> CASP2 -> CASP3 0.330953431678309cysteine-type peptidase activity(1.067e-08)Apoptosis(0.004404)TNFR1PATHWAY(8.652e-12)
ATG4B --> CASP3 ATG4B -> MAP1LC3B -> SQSTM1 -> RIPK1 -> CFLAR -> CASP8 -> CASP3 0.330953431678309cysteine-type peptidase activity(1.067e-08)Apoptosis(1.567e-06)ST_TUMOR_NECROSIS_FACTOR_PATHWAY(8.652e-12)
ATG4B --> CASP3 ATG4B -> MAP1LC3B -> SQSTM1 -> RIPK1 -> CFLAR -> CASP10 -> CASP3 0.330953431678309cysteine-type peptidase activity(1.067e-08)Apoptosis(1.567e-06)DEATHPATHWAY(1.49e-11)
ATG4B --> CASP3 ATG4B -> MAP1LC3B -> SQSTM1 -> TRAF6 -> UBC -> RIPK1 -> CRADD -> CASP2 -> CASP3 0.330522178085891caspase activity(4.206e-08)NE(1)APOPTOSIS_KEGG(3.558e-13)
ATG4B --> CASP3 ATG4B -> MAP1LC3B -> SQSTM1 -> TRAF6 -> UBC -> RIPK1 -> CFLAR -> CASP8 -> CASP3 0.330522178085891caspase activity(4.206e-08)Apoptosis(5.512e-06)REGULATION_OF_I_KAPPAB_KINASE_NF_KAPPAB_CASCADE(8.696e-12)
ATG4B --> CASP3 ATG4B -> MAP1LC3B -> SQSTM1 -> TRAF6 -> UBC -> RIPK1 -> CFLAR -> CASP10 -> CASP3 0.330522178085891caspase activity(4.206e-08)Apoptosis(5.512e-06)DEATHPATHWAY(5.358e-11)
ATG4B --> CASP3 ATG4B -> MAP1LC3B -> SQSTM1 -> RIPK1 -> CFLAR -> CASP8 -> TRAF2 -> BIRC3 -> CASP3 0.329140154118981caspase activity(4.206e-08)Apoptosis(7.538e-10)ST_TUMOR_NECROSIS_FACTOR_PATHWAY(8.212e-18)
ATG4B --> CASP3 ATG4B -> MAP1LC3B -> SQSTM1 -> TRAF6 -> UBC -> RIPK1 -> CFLAR -> CASP8 -> TRAF2 -> BIRC3 -> CASP3 0.328711263343766positive regulation of cellular process(2.486e-08)Apoptosis(4.047e-09)ST_TUMOR_NECROSIS_FACTOR_PATHWAY(4.512e-17)
*Paths limited to 15 edges